Insights into the Natural History of Vascular Ehlers-Danlos Syndrome (VEDS): Dutch Cohort Study

Screen shot of title and authors of scientific article.

A Dutch VEDS natural history was recently published. The article provides a comprehensive look at the natural history of Vascular Ehlers-Danlos syndrome (VEDS) in a Dutch cohort, involving 142 patients. The study found that males, and those with specific gene mutations or distinctive physical characteristics, are at a higher risk of experiencing serious complications at an earlier age. Major health events, such as aortic aneurysms and dissections, were noted to occur more frequently and at a younger age in men compared to women.

Key findings include:

– The average age of genetic diagnosis was 41 years.

– Aortic aneurysms and pneumothoraces were more common in men.

– Individuals with VEDS often had a characteristic appearance, which could indicate a higher risk for early major events.

– Those with a particular type of COL3A1 mutation (in the first quarter of the collagen helical domain) were more prone to aortic dissections.

This study emphasizes the need for early diagnosis and consistent monitoring to manage the severe complications associated with VEDS effectively.

For further details, refer to the full article here.